Postdoctoral Fellow

We are recruiting a postdoctoral fellow with a PhD or equivalent in Neuroscience or a related field to pursue a funded project focused on systemic regulation of neuroimmune interactions in the context of risk factors (e.g., aging) and Alzheimer's disease to start as soon as Summer 2024 (later times available). We offer an exciting environment, outstanding mentoring, and access to strong collaborations with world experts across the Loeb Center for Alzheimer’s Disease and the Friedman Brain Institute. Successful candidates will join an energetic team that uses a diverse toolset, including next-generation sequencing (scRNAseq, spatial transcriptomics), parabiosis, and in vivo microdialysis, while leveraging resources from human patient populations available to us at Mount Sinai Hospital. The lab also employs conventional methodologies, including confocal microscopy, molecular cloning techniques, viral-mediated gene transfer, and behavioral studies to understand processes of synaptic plasticity and memory in mouse models of aging and Alzheimer’s disease pathology.

Expertise in rodent handling, microscopy, and basic biochemical techniques is required. Prospective candidates should submit a cover letter, CV (including technical expertise), and contact information for three references to Dr. Joseph Castellano (see below contact).

Associate Researcher

We are recruiting a full-time Associate Researcher to start Spring/Summer 2023. Our laboratory’s research focuses on understanding how interactions between the blood/immune system and the brain influence the degree to which the brain ages and becomes susceptible to neurodegenerative disorders like Alzheimer’s disease. The successful candidate will join a growing and energetic team that uses sophisticated methods, including parabiosis, in vivo microdialysis, and next-generation sequencing (bulk, single-cell, etc) to answer questions related to disorders of memory and cognitive function. The candidate will have the opportunity to work on an independent project and to collaborate with other laboratories across the Loeb Center for AD and the Friedman Brain Institute.

The ideal candidate is independent and well-organized with a B.S./B.A. or M.S. in biological sciences, Neuroscience, or related disciplines. Work will include conventional molecular biology and in vivo methods, including mouse handling and husbandry, behavioral testing, DNA cloning, viral-mediated gene transfer, and immunohistochemistry.

Previous experience in a laboratory setting with basic laboratory expertise is required (rodent handling and basic molecular biology techniques, e.g., PCR). Interested candidates should send a cover letter, a CV, and contact information for 2-3 relevant referees to Dr. Castellano (see below contact).

Research Interns & Volunteers

We are actively seeking current undergraduate students and recent graduates who are highly motivated and looking to broaden their laboratory experience. Mentorship experiences are available for prospective individuals to learn new research techniques, work on a hypothesis-driven project, and enhance critical reasoning and technical skills in preparation for graduate or medical school.

Interested candidates should submit a submit a CV detailing any prior laboratory experience along with contact information of mentors from previous research experiences or academic professors to Dr. Joseph Castellano (see below contact).

Graduate Students

We are currently accepting both masters students and doctoral rotation students within our laboratory. Interested students should contact Dr. Joseph Castellano about potential projects and opportunities available in the lab.