Elmas A, Spehar K, Do R, Castellano JM, Huang K-L. Associations of circulating biomarkers with disease risks: A two-sample mendelian randomization study. International Journal of Molecular Sciences. 2024; 25(13):7376. doi: 10.3390/ijms25137376

Ferreira AC, Hemmer BM, Philippi SM, Grau-Perales AB, Rosenstadt JL, Liu H, Zhu JD, Kareva T, Ahfeldt T, Varghese M, Hof PR, Castellano JM. Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity. Molecular Psychiatry. 2023; doi.org/10.1038/s41380-023-02296-5

Hemmer BM, Philippi SM, Castellano JM. Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms. Trends in Molecular Medicine. 2023; doi: 10.1016/j.molmed.2023.10.007

Elahi F*, Castellano JM*, Goate AM. Advances in neurodegenerative disease research: setting the stage for new therapeutics. Science, Frontiers of Medical Research: brain science. 2023, 14-16.

*these authors contributed equally.

Ferreira AC, Hemmer BM, Philippi SM, Liu H, Zhu JD, Kareva T, Ahfeldt T, Varghese M, Hof PR, Castellano JM. Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity. BioRxiv. 2022; doi: 10.1101/2022.12.28.522138

Philippi SM, BP K, Raj T, Castellano JM, APOE genotype or presence of brain amyloid alters the plasma proteome in cognitively normal, elderly subjects. BioRxiv. 2022; doi: 10.1101/2022.12.28.522119

Betuing S, Pikuleva IA, Castellano JM. Editorial: Cholesterol and Neurodegenerative diseases - Pressing Questions and how to address them. Frontiers in Aging Neuroscience. 2022; 14:948153. doi: 10.3389/fnagi.2022.948153

Machlovi SI, Neuner SM, Hemmer BM, Khan R, Liu Y, Huang M, Zhu JD, Castellano JM, Cai D, Marcora R, Goate AM. APOE4 confers transcriptomic and functional alterations to primary mouse microglia. Neurobiology of disease. 2021; epub ahead of print. doi: 10.1016/j.nbd.2022.105615

Brigger D, Riether C, Brummelen R, Mosher KI, Shiu A, Ding Z, Zbaren N, Gasser P, Guntern P, Yousef H, Castellano JM, … , Noti M, Eggel A. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature Metabolism. 2020; 2(8): 688-702. doi: 10.1038/s42255-020-0228-3.

Ferreira AC, Castellano JM. Leaving the Lights on Using Gamma Entrainment to Protect against Neurodegeneration. Neuron. 2019; 102(5):901-902. doi:10.1016/j.neuron.2019.05.020.

Castellano JM. Blood-Based Therapies to Combat Aging. Gerontology. 2019; 65(1):84-89. doi: 10.1159/000492573. Epub 2018 Sep 7.

Castellano JM, Mosher KI, Abbey RJ, McBride AA, James ML, Berdnik D, Shen JC, Zou B, Xie XS, Tingle M, Hinkson IV, Angst MS, Wyss-Coray T. Human Umbilical Cord Plasma Proteins Revitalize Hippocampal Function in Aged Mice. Nature. 2017; 544(7651):488-92.
doi: 10.1038/nature22067.

Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T. Microglial Complement Receptor 3 Regulates Brain Abeta Levels through Secreted Proteolytic Activity. J Exp Med. 2017; 214(4):1081-92. doi: 10.1084/jem.20162011.

Castellano JM, Palner M, Freeman GM, Li S, Nguyen A, Shen B, Stan T, Mosher KI, Chin F, de Lecea L, Luo J, Wyss-Coray T. In Vivo Assessment of Behavioral Recovery and Circulatory Exchange in the Peritoneal Parabiosis Model. Scientific reports. 2016; 6:29015. doi: 10.1038/srep29015.

Zhang X, Wang H, Antaris AL, Li L, Diao S, Ma R, Nguyen A, Hong G, Ma Z, Wang J, Zhu S, Castellano JM, Wyss-Coray T, Liang Y, Luo J, Dai H. Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore. Advanced materials. 2016; 28(32):6872-9. doi: 10.1002/adma.201600706.

Castellano JM, Kirby ED, Wyss-Coray T. Blood-Borne Revitalization of the Aged Brain. JAMA neurology. 2015;72(10):1191-4. doi: 10.1001/jamaneurol.2015.1616.

Shieh P, Dien VT, Beahm BJ, Castellano JM, Wyss-Coray T, Bertozzi CR. CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum. Journal of the American Chemical Society. 2015; 137(22):7145-51. doi: 10.1021/jacs.5b02383.

Villeda SA, *Plambeck KE, *Middeldorp J, *Castellano JM, *Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo F, Wyss-Coray T. Young Blood Reverses Age-Related Impairments in Cognitive Function and Synaptic Plasticity in Mice. Nat Med. 2014; 20(6):659-63. doi: 10.1038/nm.3569.

Baruch K, Deczkowska A, David E, Castellano JM, Miller O, Kertser A, Berkutzki T, Barnett-Itzhaki Z, Bezalel D, Wyss-Coray T, Amit I, Schwartz M. Aging-Induced Type I Interferon Response at the Choroid Plexus Negatively affects Brain Function. Science. 2014; 346(6205):89-93. doi: 10.1126/science.1252945.

Luo J, Nguyen A, Villeda SA, Zhang H, Ding Z, Derek L, Bieri G, Castellano JM, Beaupre G, Wyss-Coray T. Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury. Front Neurol. 2014; 5:12. doi: 10.3389/fneur.2014.00012.

Mak A CY, Pullinger CR, Tang LF, Wong JS, Deo RC, Schwarz J-M, Gugliucci A, Movsesyan I, Ishida BY, Chu C, Poon A, Kim P, Stock EO, Schaefer EJ, Asztalos BF, Castellano JM, Wyss-Coray T, Miller BL, Jane JP, Kwok P-Y, Malloy MJ. Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function. JAMA neurology. 2014; 71(10):1228-36. doi: 10.1001/jamaneurol.2014.2011.

Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah AR, Bu G, Frieden C, Holtzman DM. ApoE Influences Amyloid-Beta (Abeta) Clearance Despite Minimal ApoE/Abeta Association in Physiological Conditions. Proc Natl Acad Sci U S A. 2013; 110(19):E1807-16. doi: 10.1073/pnas.1220484110.

Ulrich JD, Burchett III JM, Restivo JL, Schuler DR, Verghese PB, Mahan TE, Landreth GE, Castellano JM, Jiang H, Cirrito JR, Holtzman DM. In Vivo measurement of Apolipoprotein E from the Brain Interstitial fluid using Microdialysis. Molecular neurodegeneration. 2013; 8:13. doi: 10.1186/1750-1326-8-13.

Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti A, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Low-density Lipoprotein Receptor Overexpression Enhances the Rate of Brain-to-Blood Abeta Clearance in a Mouse Model of Beta-Amyloidosis. Proc Natl Acad Sci U S A. 2012; 109(38):15502-7. doi: 10.1073/pnas.1206446109.

Castellano JM, Kim J, Stewart FR, Jiang H, DeMattosRB, Patterson BW, FaganAM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human ApoE Isoforms Differentially Regulate Brain Amyloid-Beta Peptide Clearance. Sci Transl Med. 2011; 3(89):89ra57. doi: 10.1126/scitranslmed.3002156.

Verghese PB, Castellano JM, Holtzman DM. Apolipoprotein E in Alzheimer’s Disease and Other Neurological Disorders. Lancet Neurol. 2011; 10(3):241-52. doi: 10.1016/S1474-4422(10)70325-2.

Kim J, Castellano JM, Jiang H, Basak J, Parsadanian M, Pham V, Mason SM, Paul SM, Holtzman DM. Overexpression of Low-density Lipoprotein Receptor in the Brain Markedly inhibits Amyloid Deposition and Increases Extracellular A-beta Clearance. Neuron. 2009; 64(5):632-44. doi: 10.1016/j.neuron.2009.11.013.